While the share price reflects deep pessimism, many CMC Invest clients have not been deterred. CSL was the platform's most-traded individual stock in May, sitting 5th overall behind only four broad ETFs (VAS, IVV, VGS and NDQ). With 77% of orders on the buy side, client sentiment was firmly bullish.
From a technical standpoint, CSL remains in deeply oversold territory. For the entirety of May, the stock’s relative strength index stayed below the 30 point mark, a level that historically signals oversold conditions and exhaustion among sellers. Price action has been well below both 50-day and 200-day exponential moving averages ever since the company announced a shock earnings downgrade in February 2026.
With no clear positive catalyst for CSL’s turnaround, buyers appear to be focusing instead on the biotech firm’s historically cheap valuation.
Analyst sentiment reflects the broader uncertainty. TipRanks data on the CMC Invest platform paints a similarly cautious picture, with 11 analyst ratings split between just 3 buys and 8 holds, and 12-month price targets ranging from a low of A$99 to a high of A$230, with an average of A$138.
Jefferies was among those downgrading CSL in May, slashing its price target to A$108 from A$195, citing pricing pressure and competition from generics at its iron deficiency and nephrology medicine unit Vifor. The investment bank also said that a glut of immunoglobulin inventory in US-based hospitals and a slump in albumin (a blood plasma protein) prices in China have stemmed earnings growth at its CSL Behring unit, which contributed 69% of FY 2026 group revenue.
The challenges extend beyond plasma. Declining US immunisation rates have slowed momentum at the Seqirus vaccines unit, contributing to the decision to delay the spinoff.
At such a time, CSL finds itself in the middle of a management crisis. Following Paul McKenzie’s abrupt retirement in February, interim CEO Gordon Naylor, the former head of the vaccine unit, has since ruled himself out as a permanent candidate, leaving a leadership vacuum at the worst possible time.
The road to recovery may be a long one. There is a chance that buyers in May moved too early. If CSL's 18 August earnings result disappoints, the stock could come under renewed pressure.
Buyers appear focused on beaten-down prices for now. Decades of consistent compounding have earned CSL a loyal following, one that has so far proven reluctant to give up on the company despite its recent challenges.
CSL bulls remain convinced that the company can reclaim its status as a rare large cap capable of sustaining double-digit earnings growth. But, times are changing. Increased competition, changing attitudes towards vaccination and the rise of protectionism (China began developing albumin to decrease import reliance in 2025) could mean that the conditions that allowed CSL to thrive in the past may no longer exist.